Product Description: ATP synthase subunit delta, mitochondrial, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.6.3.14 (Transferred entry: 7.1.2.2)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000275 | mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) |
| Component | GO:0005739 | mitochondrion |
| Process | GO:0015986 | ATP synthesis coupled proton transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.04 | 0.98 |
| Trophozoite | expressed | 0.33 | 0.79 |
| Schizont | expressed | 0.12 | 0.91 |
| Gametocyte | possibly expressed | 0.38 | 0.78 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1147700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 1 | MFS: -1.703 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0901400)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0901400)
Modification: Disrupted | RMgm-2474
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IHP4
"Best" AlphaFill ligand hit: NOJ (moranoline, Local RMSD=0.61) with 5NGL (Global RMSD=22.04)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.6.3.14 | H+-transporting two-sector ATPase | No BRENDA inhibitors |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101225
Most Similar Human Ortholog: P30049
TM-align score: 0.79 | RMSD: 1.73
Seq Identity: 0.18 | Length: 135 / 154
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000099624 | ATP synthase F1 subunit delta |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 6 | 7 | 15 |
| disruptive | 1 | 11 | 8 | 14 |
| missense | 1 | 11 | 7 | 10 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 16 | 9 | 17 |
| disruptive | 5 | 34 | 12 | 37 |
| missense | 5 | 24 | 11 | 23 |
PlasmoDB Total SNPs: 84
Non-coding: 78 | Synonymous: 3 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 154 | Molecular Weight (kDa): 17.617
UniProt ID(s): Q8IHP4
PDB ID(s): None
Isoelectric Point: 9.63
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001469 | ATP synthase, F1 complex, delta/epsilon subunit |
| InterPro | IPR020546 | ATP synthase, F1 complex, delta/epsilon subunit, N-terminal |
| InterPro | IPR036771 | F0F1 ATP synthase delta/epsilon subunit, N-terminal |
| PFam | PF02823 | ATP synthase, F1 complex, delta/epsilon subunit, N-terminal |
| Superfamily | SSF51344 | F0F1 ATP synthase delta/epsilon subunit, N-terminal |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 21984828 | ATP synthase complex of Plasmodium falciparum: dimeric assembly in mitochondrialmembranes and resistance to genetic disruption. | Nina PB, Morrisey JM, ..., Vaidya AB | 10.1074/jbc.M111.290973 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |