Genome location: Pf3D7_11_v3:1,906,472..1,908,483(-)
Genome classification: Core
Product Description: peroxisome assembly protein 22, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB): None
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.08 | 0.96 |
| Trophozoite | expressed | 0.15 | 0.89 |
| Schizont | expressed | 0.27 | 0.81 |
| Gametocyte | expressed | 0.28 | 0.83 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1147900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.141 | MFS: -3.386 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0901200)
Modification: Disrupted | RMgm-2473
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IHP2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 1 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 1 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 109
Non-coding: 103 | Synonymous: 3 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 217 | Molecular Weight (kDa): 24.916
UniProt ID(s): Q8IHP2
PDB ID(s): None
Isoelectric Point: 9.53
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR037485 | Peroxisome biogenesis protein 22 |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 28552664 | Saccharomyces cerevisiae cells lacking Pex3 contain membrane vesicles that harbora subset of peroxisomal membrane proteins | Wroblewska JP, Cruz-Zaragoza LD, ..., van der Klei IJ | 10.1016/j.bbamcr.2017.05.021 |
| 15632140 | The Saccharomyces cerevisiae peroxisomal import receptor Pex5p ismonoubiquitinated in wild type cells | Kragt A, Voorn-Brouwer T, van den Berg M, Distel B | 10.1074/jbc.M413553200 |
| 10806427 | The CUP1 promoter of Saccharomyces cerevisiae is inducible by copper in Pichiapastoris | Koller A, Valesco J, Subramani S | 10.1002/(SICI)1097-0061(200005)16:7<651::AID-YEA580>3.0.CO;2-F |
| 28919252 | Mutation in the peroxin-coding gene PEX22 contributing to high malate productionin Saccharomyces cerevisiae | Negoro H, Sakamoto M, ..., Hata Y | 10.1016/j.jbiosc.2017.08.010 |