Genome location: Pf3D7_11_v3:1,933,278..1,937,217(-)
Genome classification: Core
Product Description: Plasmodium exported protein (PHISTc), unknown function
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0033644 | host cell membrane |
| Component | GO:0044538 | host cell periphery |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.48 | 0.80 |
| Trophozoite | expressed | 0.18 | 0.91 |
| Schizont | possibly expressed | 0.05 | 0.97 |
| Gametocyte | not expressed | 0.57 | 0.71 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1148700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.386 | MFS: -2.739 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IHN7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_114263
Most Similar Human Ortholog: Q9BYR4
TM-align score: 0.25 | RMSD: 5.31
Seq Identity: 0.05 | Length: 82 / 370
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000196156 | keratin associated protein 4-3 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 3 | 2 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 3 | 2 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 230
Non-coding: 167 | Synonymous: 32 | Nonsynonymous: 31 | Stop Codon: 0
Protein Length: 370 | Molecular Weight (kDa): 43.788
UniProt ID(s): Q8IHN7
PDB ID(s): None
Isoelectric Point: 9.18
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR019111 | Plasmodium RESA, N-terminal |
| PFam | PF09687 | Plasmodium RESA, N-terminal |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 27777305 | Expansion of Lysine-rich Repeats in Plasmodium Proteins Generates NovelLocalization Sequences That Target the Periphery of the Host Erythrocyte. | Davies HM, Thalassinos K, Osborne AR | 10.1074/jbc.M116.761213 |
| 29154995 | A map of the subcellular distribution of phosphoinositides in the erythrocyticcycle of the malaria parasite Plasmodium falciparum. | Ebrahimzadeh Z, Mukherjee A, Richard D | 10.1016/j.ijpara.2017.08.015 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |