About Gene List

PF3D7_1148800

Genome location: Pf3D7_11_v3:1,940,627..1,942,588(+)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (hyp11), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0043657 host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.29 0.85
Trophozoite not expressed 0.05 0.97
Schizont not expressed 0.02 0.99
Gametocyte not expressed 0.02 0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1148800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.514 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHN6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533000

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 12 7 15
disruptive 17 51 18 39
missense 10 47 15 32

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 26 4 18
disruptive 26 70 30 62
missense 17 61 21 46

PlasmoDB Total SNPs: 56

Non-coding: 25 | Synonymous: 15 | Nonsynonymous: 16 | Stop Codon: 0

Protein Information

Protein Length: 372 | Molecular Weight (kDa): 45.099

UniProt ID(s): Q8IHN6

PDB ID(s): None

Isoelectric Point: 3.95

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006496 Conserved hypothetical protein CHP01609, Plasmodium spp
PFam PF09688 Conserved hypothetical protein CHP01609, Plasmodium spp
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
16507167 Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. Sargeant TJ, Marti M, ..., Cowman AF 10.1186/gb-2006-7-2-r12