Product Description: Plasmodium exported protein (hyp11), unknown function
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0043657 | host cell |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | not expressed | N/A | N/A |
Ring | not expressed | 0.29 | 0.85 |
Trophozoite | not expressed | 0.05 | 0.97 |
Schizont | not expressed | 0.02 | 0.99 |
Gametocyte | not expressed | 0.02 | 0.99 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1148800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.514 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IHN6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 5 | 12 | 7 | 15 |
disruptive | 17 | 51 | 18 | 39 |
missense | 10 | 47 | 15 | 32 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 6 | 26 | 4 | 18 |
disruptive | 26 | 70 | 30 | 62 |
missense | 17 | 61 | 21 | 46 |
PlasmoDB Total SNPs: 56
Non-coding: 25 | Synonymous: 15 | Nonsynonymous: 16 | Stop Codon: 0
Protein Length: 372 | Molecular Weight (kDa): 45.099
UniProt ID(s): Q8IHN6
PDB ID(s): None
Isoelectric Point: 3.95
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR006496 | Conserved hypothetical protein CHP01609, Plasmodium spp |
PFam | PF09688 | Conserved hypothetical protein CHP01609, Plasmodium spp |
Superfamily | N/A | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
16507167 | Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. | Sargeant TJ, Marti M, ..., Cowman AF | 10.1186/gb-2006-7-2-r12 |