Genome location: Pf3D7_11_v3:1,975,705..1,980,325(+)
Genome classification: Core
Product Description: ring-infected erythrocyte surface antigen
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 3.49 | 0.11 |
| Trophozoite | possibly expressed | 1.41 | 0.41 |
| Schizont | expressed | 1.42 | 0.37 |
| Gametocyte | not expressed | 0.92 | 0.59 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1149200
Resistome Missense Mutations: E486D
Resistome Compounds with Missense Mutations: Proguanil
Resistome # Samples with Disruptive Mutations: 2 (2 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.517 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IHN1
"Best" AlphaFill ligand hit: 1PS (3-pyridinium-1-ylpropane-1-sulfonate, Local RMSD=2.63) with 5AYK (Global RMSD=8.84)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 16 | 24 | 14 | 33 |
| disruptive | 133 | 150 | 78 | 173 |
| missense | 103 | 112 | 64 | 129 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 23 | 33 | 22 | 37 |
| disruptive | 158 | 263 | 96 | 202 |
| missense | 120 | 199 | 76 | 134 |
PlasmoDB Total SNPs: 266
Non-coding: 42 | Synonymous: 65 | Nonsynonymous: 156 | Stop Codon: 3
Protein Length: 1090 | Molecular Weight (kDa): 126.917
UniProt ID(s): Q7M3R2, Q8IHN1, Q8MPL0
PDB ID(s): None
Isoelectric Point: 4.16
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001623 | DnaJ domain |
| InterPro | IPR018253 | DnaJ domain, conserved site |
| InterPro | IPR019111 | Plasmodium RESA, N-terminal |
| InterPro | IPR026894 | DNAJ-containing protein, X-domain |
| InterPro | IPR036869 | Chaperone J-domain superfamily |
| PFam | PF00226 | DnaJ domain |
| PFam | PF09687 | Plasmodium RESA, N-terminal |
| PFam | PF14308 | DNAJ-containing protein, X-domain |
| Superfamily | SSF46565 | Chaperone J-domain superfamily |
| Superfamily | SSF69349 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |
| 15853885 | A role for the Plasmodium falciparum RESA protein in resistance against heatshock demonstrated using gene disruption | Silva MD, Cooke BM, ..., Bonnefoy S | 10.1111/j.1365-2958.2005.04603.x |
| 26178656 | Immunoglobulin response to Plasmodium falciparum RESA proteins in uncomplicatedand severe malaria | Badaut C, Guyonnet L, ..., Migot-Nabias F | 10.1186/s12936-015-0799-8 |