Genome location: Pf3D7_12_v3:57,076..57,435(-)
Genome classification: SubtelomericHypervariable
Product Description: VAR2CSA uORF
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0045182 | translation regulator activity |
| Process | GO:0006417 | regulation of translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.14 | 0.94 |
| Trophozoite | no data | 0.02 | 0.99 |
| Schizont | no data | 0.01 | 0.99 |
| Gametocyte | no data | 0.01 | 1.00 |
More info:
No corresponding Pf3D7v3 gene ID in resistome database
Zhang Phenotype: N/A
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A144A041
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 0
Non-coding: 0 | Synonymous: 0 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 119 | Molecular Weight (kDa): 13.707
UniProt ID(s): A0A144A041
PDB ID(s): None
Isoelectric Point: 8.84
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 19119419 | An upstream open reading frame controls translation of var2csa, a gene implicatedin placental malaria. | Amulic B, Salanti A, ..., Deitsch KW | 10.1371/journal.ppat.1000256 |
| 31098405 | Single-molecule imaging and quantification of the immune-variant adhesin VAR2CSAon knobs of Plasmodium falciparum-infected erythrocytes. | Sanchez CP, Karathanasis C, ..., Lanzer M | 10.1038/s42003-019-0429-z |
| 31740695 | VAR2CSA binding phenotype has ancient origin and arose before Plasmodiumfalciparum crossed to humans: implications in placental malaria vaccine design. | Gangnard S, Chene A, ..., Gamain B | 10.1038/s41598-019-53334-8 |
| 32244341 | Optimization of r VAR2-Based Isolation of Cancer Cells in Blood for Building a Robust Assay for Clinical Detection of Circulating Tumor Cells | Sand NT, Petersen TB, ..., Agerbaek MO | 10.3390/ijms21072401 |
| 33633743 | VAR2CSA-Mediated Host Defense Evasion of Plasmodium falciparum InfectedErythrocytes in Placental Malaria. | Tomlinson A, Semblat JP, Gamain B, Chene A | 10.3389/fimmu.2020.624126 |
| 34220804 | High Antibodies to VAR2CSA in Response to Malaria Infection Are Associated WithImproved Birthweight in a Longitudinal Study of Pregnant Women. | McLean ARD, Opi DH, ..., Fowkes FJI | 10.3389/fimmu.2021.644563 |
| 34762909 | The specificity of the malarial VAR2CSA protein for chondroitin sulfate dependson 4-O-sulfation and ligand accessibility. | Spliid CB, Toledo AG, ..., Clausen TM | 10.1016/j.jbc.2021.101391 |