About Gene List

PF3D7_1200900

Genome location: Pf3D7_12_v3:72,605..75,379(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (PHISTc), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0030430 host cell cytoplasm

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 1.16 0.50
Trophozoite possibly expressed 0.65 0.64
Schizont not expressed 0.27 0.82
Gametocyte not expressed 0.22 0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1200900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.31 | MFS: -2.581 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I636

"Best" AlphaFill ligand hit: CHT (choline ion, Local RMSD=0.96) with 3C5I (Global RMSD=20.93)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533137

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 10 0 10
disruptive 11 23 18 43
missense 8 22 18 38

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 4 12 5 17
disruptive 13 60 34 68
missense 10 45 30 53

PlasmoDB Total SNPs: 112

Non-coding: 63 | Synonymous: 39 | Nonsynonymous: 10 | Stop Codon: 0

Protein Information

Protein Length: 383 | Molecular Weight (kDa): 46.247

UniProt ID(s): Q8I636

PDB ID(s): None

Isoelectric Point: 7.41

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006526 Exported protein, PHISTa/b/c, conserved domain, Plasmodium
InterPro IPR019111 Plasmodium RESA, N-terminal
PFam PF09687 Plasmodium RESA, N-terminal
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
25850860 The Plasmodium falciparum exportome contains non-canonical PEXEL/HT proteins. Schulze J, Kwiatkowski M, ..., Pick C 10.1111/mmi.13024