Product Description: Plasmodium exported protein (PHISTb), unknown function
SignalP Peptide: MYSALRSFLFRKSVVSVIG
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0044538 | host cell periphery |
| Component | GO:0044228 | host cell surface |
| Component | GO:0020030 | infected host cell surface knob |
| Component | GO:0005634 | nucleus |
| Component | GO:0020003 | symbiont-containing vacuole |
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.35 | 0.85 |
| Trophozoite | expressed | 1.29 | 0.47 |
| Schizont | expressed | 0.11 | 0.94 |
| Gametocyte | not expressed | 0.12 | 0.94 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1201000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.967 | MFS: -2.448 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I635
"Best" AlphaFill ligand hit: GTP (guanosine-5'-triphosphate, Local RMSD=6.42) with 7VEX (Global RMSD=21.42)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 11 | 7 | 23 |
| disruptive | 34 | 52 | 29 | 73 |
| missense | 19 | 38 | 18 | 53 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 21 | 9 | 22 |
| disruptive | 48 | 89 | 68 | 92 |
| missense | 28 | 63 | 51 | 54 |
PlasmoDB Total SNPs: 202
Non-coding: 86 | Synonymous: 61 | Nonsynonymous: 55 | Stop Codon: 0
Protein Length: 653 | Molecular Weight (kDa): 77.116
UniProt ID(s): Q8I635
PDB ID(s): None
Isoelectric Point: 4.14
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR019111 | Plasmodium RESA, N-terminal |
| PFam | PF09687 | Plasmodium RESA, N-terminal |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 27777305 | Expansion of Lysine-rich Repeats in Plasmodium Proteins Generates NovelLocalization Sequences That Target the Periphery of the Host Erythrocyte. | Davies HM, Thalassinos K, Osborne AR | 10.1074/jbc.M116.761213 |
| 28981210 | Proteome and Structural Organization of the Knob Complex on the Surface of thePlasmodium Infected Red Blood Cell. | Alampalli SV, Grover M, ..., Acharya P | 10.1002/prca.201600177 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33774908 | Characterisation of complexes formed by parasite proteins exported into the hostcell compartment of Plasmodium falciparum infected red blood cells. | Jonsdottir TK, Counihan NA, ..., Gilson PR | 10.1111/cmi.13332 |