PF3D7_1201200

Genome location: Pf3D7_12_v3:88,326..92,048(+)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (PHISTa-like), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020036	Maurer's cleft
Component	GO:0043657	host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	1.72	0.35
Trophozoite	expressed	0.31	0.83
Schizont	expressed	0.33	0.80
Gametocyte	possibly expressed	0.25	0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1201200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.873 | MFS: -2.551 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I633

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533667

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 150

Non-coding: 131 | Synonymous: 13 | Nonsynonymous: 4 | Stop Codon: 2

Protein Information

Protein Length: 221 | Molecular Weight (kDa): 25.876

UniProt ID(s): Q8I633

PDB ID(s): None

Isoelectric Point: 6.35

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006526	Exported protein, PHISTa/b/c, conserved domain, Plasmodium
InterPro	IPR019111	Plasmodium RESA, N-terminal
PFam	PF09687	Plasmodium RESA, N-terminal
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094
16507167	Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites.	Sargeant TJ, Marti M, ..., Cowman AF	10.1186/gb-2006-7-2-r12
31631203	A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum.	Das D, Krishnan SR, Roy A, Bulusu G	10.1039/c9mo00124g