About Gene List

PF3D7_1201300 (LSAP1)

Genome location: Pf3D7_12_v3:92,242..92,562(+)

Genome classification: Core

Function and Localization

Product Description: liver stage associated protein 1

SignalP Peptide: MKTIIIVTLFILILNTIIINPCTC

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring not expressed 0.02 0.99
Trophozoite not expressed 0.01 1.00
Schizont possibly expressed 0.00 1.00
Gametocyte not expressed 0.02 0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1201300

Resistome Missense Mutations: D47E, D47N, N49K

Resistome Compounds with Missense Mutations: KAE678/NITD678

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.146 | MFS: -3.281 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I632

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532599

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 3 3 1
disruptive 6 5 0 3
missense 6 5 0 3

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 7 2 1
disruptive 7 9 7 15
missense 7 6 5 8

PlasmoDB Total SNPs: 8

Non-coding: 0 | Synonymous: 3 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 106 | Molecular Weight (kDa): 12.267

UniProt ID(s): Q8I632

PDB ID(s): None

Isoelectric Point: 5.05

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006389 Early transcribed membrane protein (ETRAMP)
PFam PF09716 Early transcribed membrane protein (ETRAMP)
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23950716 Identification of new PNEPs indicates a substantial non-PEXEL exportome andunderpins common features in Plasmodium falciparum protein export. Heiber A, Kruse F, ..., Spielmann T 10.1371/journal.ppat.1003546