About Gene List

PF3D7_1201400

Genome location: Pf3D7_12_v3:93,581..97,146(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0043657 host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.10 0.95
Trophozoite not expressed 0.13 0.93
Schizont possibly expressed 0.03 0.98
Gametocyte possibly expressed 0.16 0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1201400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.945 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I631

"Best" AlphaFill ligand hit: PGO (s-1,2-propanediol, Local RMSD=0.10) with 4KS6 (Global RMSD=16.54)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533539

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 22 7 29
disruptive 130 138 43 124
missense 114 108 39 101

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 8 36 21 39
disruptive 170 218 94 177
missense 145 170 69 107

PlasmoDB Total SNPs: 336

Non-coding: 11 | Synonymous: 165 | Nonsynonymous: 160 | Stop Codon: 0

Protein Information

Protein Length: 1129 | Molecular Weight (kDa): 132.462

UniProt ID(s): Q8I631

PDB ID(s): None

Isoelectric Point: 3.99

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16507167 Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. Sargeant TJ, Marti M, ..., Cowman AF 10.1186/gb-2006-7-2-r12