Product Description: GPN-loop GTPase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0005524 | ATP binding |
| Function | GO:0016887 | ATP hydrolysis activity |
| Function | GO:0003924 | GTPase activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.55 | 0.74 |
| Trophozoite | expressed | 0.46 | 0.75 |
| Schizont | expressed | 0.07 | 0.96 |
| Gametocyte | expressed | 0.45 | 0.74 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1201500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.122 | MFS: -3.045 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I630
"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=0.05) with 5HCI (Global RMSD=1.18)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101544
Most Similar Human Ortholog: Q9HCN4
TM-align score: 0.75 | RMSD: 1.65
Seq Identity: 0.46 | Length: 291 / 497
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000198522 | GPN-loop GTPase 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 8 | 6 | 21 |
| disruptive | 13 | 31 | 21 | 57 |
| missense | 8 | 27 | 19 | 50 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 26 | 12 | 23 |
| disruptive | 24 | 68 | 40 | 114 |
| missense | 13 | 49 | 32 | 83 |
PlasmoDB Total SNPs: 98
Non-coding: 65 | Synonymous: 16 | Nonsynonymous: 17 | Stop Codon: 0
Protein Length: 497 | Molecular Weight (kDa): 57.644
UniProt ID(s): Q8I630
PDB ID(s): None
Isoelectric Point: 5.49
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004130 | GPN-loop GTPase |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR030230 | GPN-loop GTPase 1 |
| PFam | PF03029 | GPN-loop GTPase |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |