PF3D7_1201700

Genome location: Pf3D7_12_v3:103,318..104,985(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.10	0.93
Schizont	possibly expressed	0.06	0.96
Gametocyte	possibly expressed	0.69	0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1201700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.179 | MFS: -2.897 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I628

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532689

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	9	3	8
disruptive	6	14	13	20
missense	6	14	12	17

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	12	8	12
disruptive	11	37	26	68
missense	7	29	22	46

PlasmoDB Total SNPs: 77

Non-coding: 54 | Synonymous: 15 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 247 | Molecular Weight (kDa): 29.671

UniProt ID(s): Q8I628

PDB ID(s): None

Isoelectric Point: 8.53

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A