Product Description: cytochrome c oxidase assembly protein COX19, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005758 | mitochondrial intermembrane space |
| Component | GO:0005739 | mitochondrion |
| Process | GO:0033617 | mitochondrial cytochrome c oxidase assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.07 | 0.97 |
| Trophozoite | not expressed | 0.50 | 0.70 |
| Schizont | not expressed | 0.16 | 0.89 |
| Gametocyte | not expressed | 0.27 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1201800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.139 | MFS: -3.104 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0600800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I627
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103881
Most Similar Human Ortholog: Q49B96
TM-align score: 0.67 | RMSD: 2.73
Seq Identity: 0.45 | Length: 74 / 218
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000240230 | cytochrome c oxidase assembly factor COX19 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 8 | 5 | 9 |
| disruptive | 2 | 24 | 5 | 41 |
| missense | 2 | 21 | 3 | 33 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 17 | 5 | 16 |
| disruptive | 11 | 49 | 32 | 54 |
| missense | 5 | 45 | 27 | 36 |
PlasmoDB Total SNPs: 60
Non-coding: 53 | Synonymous: 4 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 218 | Molecular Weight (kDa): 26.16
UniProt ID(s): Q8I627
PDB ID(s): None
Isoelectric Point: 8.58
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR010625 | CHCH |
| PFam | PF06747 | CHCH |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 37348640 | Expression and copper binding studies of a Plasmodium falciparum protein withCox19 copper binding motifs | Salman AA, Goldring JPD | 10.1016/j.exppara.2023.108572 |