About Gene List

PF3D7_1202100 (SRAP1)

Genome location: Pf3D7_12_v3:113,340..116,410(+)

Genome classification: Core

Function and Localization

Product Description: SRAP domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed nd nd
Trophozoite expressed nd nd
Schizont expressed nd nd
Gametocyte expressed nd nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1202100.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.53 | MFS: -2.382 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I624

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102318

Most Similar Human Ortholog: D6RAZ3

TM-align score: 0.77 | RMSD: 3.00

Seq Identity: 0.27 | Length: 208 / 401

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000183624 5-hydroxymethylcytosine binding, ES cell specific

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 9 20 9 13
disruptive 23 63 27 41
missense 15 48 20 33

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 14 30 9 22
disruptive 37 117 42 95
missense 24 78 32 61

PlasmoDB Total SNPs: 209

Non-coding: 135 | Synonymous: 42 | Nonsynonymous: 31 | Stop Codon: 1

Protein Information

Protein Length: 401 | Molecular Weight (kDa): 46.668

UniProt ID(s): Q8I624

PDB ID(s): None

Isoelectric Point: 5.07

Protein Domain Annotations:

Source Family ID Description
InterPro IPR003738 SOS response associated peptidase (SRAP)
InterPro IPR036590 SOS response associated peptidase-like
PFam PF02586 SOS response associated peptidase (SRAP)
Superfamily SSF143081 SOS response associated peptidase-like

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097