Product Description: mitochondrial phosphate carrier protein
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0031305 | integral component of mitochondrial inner membrane |
| Component | GO:0005743 | mitochondrial inner membrane |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0005315 | inorganic phosphate transmembrane transporter activity |
| Process | GO:0035435 | phosphate ion transmembrane transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | possibly expressed | 0.03 | 0.98 |
| Trophozoite | expressed | 0.36 | 0.78 |
| Schizont | expressed | 0.42 | 0.74 |
| Gametocyte | expressed | 0.41 | 0.76 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1202200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.736 | MFS: -2.302 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0601100)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I623
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101022
Most Similar Human Ortholog: Q00325
TM-align score: 0.90 | RMSD: 2.23
Seq Identity: 0.44 | Length: 310 / 324
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000075415 | solute carrier family 25 member 3 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 19 | 8 | 9 |
| disruptive | 4 | 18 | 7 | 31 |
| missense | 4 | 18 | 7 | 29 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 28 | 6 | 11 |
| disruptive | 12 | 38 | 29 | 78 |
| missense | 10 | 33 | 25 | 55 |
PlasmoDB Total SNPs: 82
Non-coding: 63 | Synonymous: 13 | Nonsynonymous: 6 | Stop Codon: 0
Protein Length: 324 | Molecular Weight (kDa): 36.801
PDB ID(s): None
Isoelectric Point: 9.97
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR018108 | Mitochondrial substrate/solute carrier |
| InterPro | IPR023395 | Mitochondrial carrier domain superfamily |
| PFam | PF00153 | Mitochondrial substrate/solute carrier |
| Superfamily | SSF103506 | Mitochondrial carrier domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 32574727 | Characterization of mitochondrial carrier proteins of malaria parasite Plasmodiumfalciparum based on in vitro translation and reconstitution. | Nozawa A, Ito D, ..., Tozawa Y | 10.1016/j.parint.2020.102160 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 38380127 | N-Substituted Phenylhydrazones Kill the Ring Stage of Plasmodium falciparum | Amengor CDK, Biniyam PD, ..., Abudey BM | 10.1155/2024/6697728 |