PF3D7_1202300

Genome location: Pf3D7_12_v3:118,603..141,499(+)

Genome classification: Core

Function and Localization

Product Description: dynein heavy chain, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005930	axoneme
Component	GO:0030286	dynein complex
Function	GO:0045505	dynein intermediate chain binding
Function	GO:0051959	dynein light intermediate chain binding
Function	GO:0008569	minus-end-directed microtubule motor activity
Process	GO:0007018	microtubule-based movement

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.14	0.93
Trophozoite	not expressed	0.33	0.83
Schizont	not expressed	0.46	0.76
Gametocyte	not expressed	1.73	0.33

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1202300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.865 | #Insertions: 30

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0601200)

Relative Growth Rate: 0.71 ± 0.23
Confidence: 4.33

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0601200)

Modification: Disrupted | RMgm-2054

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532796

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	64	336	190	338
disruptive	139	659	399	881
missense	117	612	370	766

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	134	629	246	372
disruptive	312	1444	614	1317
missense	236	1195	525	934

PlasmoDB Total SNPs: 1265

Non-coding: 814 | Synonymous: 263 | Nonsynonymous: 188 | Stop Codon: 0

Protein Information

Protein Length: 5718 | Molecular Weight (kDa): 690.136

UniProt ID(s): A0A144A1B4

PDB ID(s): None

Isoelectric Point: 9.42

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR026983	Dynein heavy chain
PFam	N/A	N/A
Superfamily	N/A	N/A