Product Description: peptidyl-prolyl cis-trans isomerase
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 5.2.1.8 (Peptidylprolyl isomerase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Function | GO:0016018 | cyclosporin A binding |
| Function | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity |
| Process | GO:0006457 | protein folding |
| Process | GO:0000413 | protein peptidyl-prolyl isomerization |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.01 | 0.99 |
| Trophozoite | expressed | 0.07 | 0.96 |
| Schizont | expressed | 0.04 | 0.97 |
| Gametocyte | expressed | 0.05 | 0.97 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1202400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.599 | MFS: -2.292 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I621
"Best" AlphaFill ligand hit: LSA (saccharin, Local RMSD=0.05) with 4N1O (Global RMSD=1.04)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 5.2.1.8 | peptidylprolyl isomerase | ATPNEMSDSPCMBFK506QAEGPKAla-ProjugloneSer-ProGPI-1046RNase T1Rapamycin... |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P10111 | Peptidyl-prolyl cis-trans isomerase A | Rattus norvegicus | HOGENOM | CHEMBL13611CHEMBL441409CHEMBL13778CHEMBL13768... |
Protein Length: 226 | Molecular Weight (kDa): 26.429
UniProt ID(s): Q8I621
PDB ID(s): None
Isoelectric Point: 8.44
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002130 | Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain |
| InterPro | IPR029000 | Cyclophilin-like domain superfamily |
| PFam | PF00160 | Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain |
| Superfamily | SSF50891 | Cyclophilin-like domain superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 14 | 7 | 15 |
| disruptive | 1 | 8 | 3 | 11 |
| missense | 1 | 8 | 3 | 11 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 25 | 7 | 17 |
| disruptive | 3 | 19 | 15 | 41 |
| missense | 2 | 17 | 10 | 31 |
PlasmoDB Total SNPs: 203
Non-coding: 192 | Synonymous: 6 | Nonsynonymous: 5 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 22546550 | A family of cyclophilin-like molecular chaperones in Plasmodium falciparum. | Marin-Menendez A, Monaghan P, Bell A | 10.1016/j.molbiopara.2012.04.006 |