Product Description: nuclear export mediator factor NEMF, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:1990112 | RQC complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0043023 | ribosomal large subunit binding |
| Function | GO:0000049 | tRNA binding |
| Process | GO:0051168 | nuclear export |
| Process | GO:0072344 | rescue of stalled ribosome |
| Process | GO:1990116 | ribosome-associated ubiquitin-dependent protein catabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.46 | 0.39 |
| Trophozoite | expressed | 1.89 | 0.22 |
| Schizont | expressed | 2.48 | 0.11 |
| Gametocyte | expressed | 1.84 | 0.21 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1202600
Resistome Missense Mutations: K1309I
Resistome Compounds with Missense Mutations: DSM1
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.215 | MFS: -2.72 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A144A0J9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101297
Most Similar Human Ortholog: G3V547
TM-align score: 0.95 | RMSD: 1.32
Seq Identity: 0.46 | Length: 121 / 2180
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000165525 | nuclear export mediator factor |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 26 | 140 | 60 | 144 |
| disruptive | 88 | 396 | 189 | 392 |
| missense | 59 | 337 | 167 | 338 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 47 | 231 | 88 | 162 |
| disruptive | 153 | 691 | 280 | 526 |
| missense | 101 | 588 | 243 | 410 |
PlasmoDB Total SNPs: 397
Non-coding: 121 | Synonymous: 131 | Nonsynonymous: 145 | Stop Codon: 0
Protein Length: 2180 | Molecular Weight (kDa): 254.296
UniProt ID(s): A0A144A0J9
PDB ID(s): None
Isoelectric Point: 7.85
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR008532 | NFACT, RNA-binding domain |
| InterPro | IPR021846 | NFACT protein, C-terminal |
| PFam | PF05670 | NFACT, RNA-binding domain |
| PFam | PF05833 | NFACT protein, C-terminal |
| PFam | PF11923 | |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |