Product Description: AATF domain-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005730 | nucleolus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.55 | 0.74 |
| Trophozoite | expressed | 0.32 | 0.82 |
| Schizont | possibly expressed | 0.09 | 0.95 |
| Gametocyte | not expressed | 0.24 | 0.86 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1202700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.226 | MFS: -2.862 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0601700)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I618
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102684
Most Similar Human Ortholog: A0A7P0TBI0
TM-align score: 0.41 | RMSD: 5.29
Seq Identity: 0.11 | Length: 217 / 412
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000275700 | apoptosis antagonizing transcription factor |
| ENSG00000276072 | apoptosis antagonizing transcription factor |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 27 | 12 | 30 |
| disruptive | 11 | 60 | 38 | 77 |
| missense | 10 | 53 | 36 | 69 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 53 | 19 | 30 |
| disruptive | 24 | 133 | 61 | 156 |
| missense | 13 | 115 | 50 | 88 |
PlasmoDB Total SNPs: 302
Non-coding: 266 | Synonymous: 24 | Nonsynonymous: 12 | Stop Codon: 0
Protein Length: 412 | Molecular Weight (kDa): 49.184
UniProt ID(s): Q8I618
PDB ID(s): None
Isoelectric Point: 9.35
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR012617 | Apoptosis-antagonizing transcription factor, C-terminal |
| InterPro | IPR025160 | AATF leucine zipper-containing domain |
| InterPro | IPR039223 | Protein AATF/Bfr2 |
| PFam | PF08164 | Apoptosis-antagonizing transcription factor, C-terminal |
| PFam | PF13339 | AATF leucine zipper-containing domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |