Product Description: high mobility group protein B1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005694 | chromosome |
| Component | GO:0005829 | cytosol |
| Component | GO:0005634 | nucleus |
| Function | GO:0008301 | DNA binding, bending |
| Function | GO:0019237 | centromeric DNA binding |
| Process | GO:0001819 | positive regulation of cytokine production |
| Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Process | GO:0006355 | regulation of transcription, DNA-templated |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 2.21 | 0.20 |
| Trophozoite | expressed | 2.31 | 0.14 |
| Schizont | expressed | 1.36 | 0.37 |
| Gametocyte | expressed | 0.75 | 0.61 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1202900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.339 | MFS: -2.546 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I616
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100324
Most Similar Human Ortholog: E7EQU1
TM-align score: 0.78 | RMSD: 2.26
Seq Identity: 0.40 | Length: 90 / 97
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000029993 | high mobility group box 3 |
| ENSG00000189403 | high mobility group box 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 1 | 1 | 1 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 1 |
| disruptive | 2 | 1 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 158
Non-coding: 158 | Synonymous: 0 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 97 | Molecular Weight (kDa): 11.331
UniProt ID(s): Q25871, Q8I616, Q9U467
PDB ID(s): None
Isoelectric Point: 10.68
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR009071 | High mobility group box domain |
| InterPro | IPR036910 | High mobility group box domain superfamily |
| PFam | PF00505 | High mobility group box domain |
| Superfamily | SSF47095 | High mobility group box domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16607015 | High-mobility-group box nuclear factors of Plasmodium falciparum. | Briquet S, Boschet C, ..., Vaquero C | 10.1128/EC.5.4.672-682.2006 |
| 18234548 | High mobility group box (HMGB) proteins of Plasmodium falciparum: DNA bindingproteins with pro-inflammatory activity. | Kumar K, Singal A, Rizvi MM, Chauhan VS | 10.1016/j.parint.2007.11.005 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906919 | The Architectural Factor H MGB1 Is Involved in Genome Organization in the Human Malaria Parasite Plasmodium falciparum | Lu B, Liu M, ..., Zhang Q | 10.1128/mBio.00148-21 |
| 38369488 | Lipopolysaccharide, VE-cadherin, HMGB1, and HIF-1alpha levels are elevated in thesystemic circulation in chronic migraine patients with medication overuseheadache: evidence of leaky gut and inflammation | Vuralli D, Ceren Akgor M, ..., Bolay H | 10.1186/s10194-024-01730-5 |
| 38380574 | Bletilla striata polysaccharides protect against ARDS by modulating theNLRP3/caspase1/GSDMD and HMGB1/TLR4 signaling pathways to improve pulmonaryalveolar macrophage pyroptosis | Wu Q, Zhou M, ..., Ding Z | 10.1016/j.jep.2023.117361 |