Product Description: origin recognition complex subunit 1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0005664 | nuclear origin of replication recognition complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0016887 | ATP hydrolysis activity |
| Function | GO:0003688 | DNA replication origin binding |
| Function | GO:0042162 | telomeric DNA binding |
| Process | GO:0006270 | DNA replication initiation |
| Process | GO:0033314 | mitotic DNA replication checkpoint signaling |
| Process | GO:0000278 | mitotic cell cycle |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.38 | 0.82 |
| Trophozoite | expressed | 0.91 | 0.53 |
| Schizont | expressed | 0.55 | 0.70 |
| Gametocyte | expressed | 0.90 | 0.57 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1203000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.937 | MFS: -2.52 | #Insertions: 1
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0602000)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I615
"Best" AlphaFill ligand hit: ACP (adenosine-5'-[beta, gamma-methylene]triphosphate, Local RMSD=0.06) with 2HCB (Global RMSD=7.25)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100406
Most Similar Human Ortholog: Q99741
TM-align score: 0.66 | RMSD: 4.41
Seq Identity: 0.25 | Length: 431 / 1189
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000085840 | origin recognition complex subunit 1 |
| ENSG00000094804 | cell division cycle 6 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 71 | 38 | 72 |
| disruptive | 17 | 121 | 70 | 152 |
| missense | 12 | 108 | 63 | 127 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 25 | 132 | 56 | 85 |
| disruptive | 54 | 260 | 129 | 307 |
| missense | 35 | 202 | 109 | 220 |
PlasmoDB Total SNPs: 117
Non-coding: 21 | Synonymous: 62 | Nonsynonymous: 34 | Stop Codon: 0
Protein Length: 1189 | Molecular Weight (kDa): 138.738
UniProt ID(s): A0A144A1W6, Q8I615
PDB ID(s): None
Isoelectric Point: 10.08
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003593 | AAA+ ATPase domain |
| InterPro | IPR003959 | ATPase, AAA-type, core |
| InterPro | IPR020793 | Origin recognition complex, subunit 1 |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR041083 | AAA lid domain |
| PFam | PF00004 | ATPase, AAA-type, core |
| PFam | PF17872 | AAA lid domain |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16216221 | Expression and characterization of human malaria parasite Plasmodium falciparumorigin recognition complex subunit 1. | Mehra P, Biswas AK, ..., Dhar SK | 10.1016/j.bbrc.2005.09.131 |
| 16842352 | Analogous expression pattern of Plasmodium falciparum replication initiationproteins PfMCM4 and PfORC1 during the asexual and sexual stages ofintraerythrocytic developmental cycle. | Gupta A, Mehra P, ..., Dhar SK | 10.1111/j.1574-6968.2006.00324.x |
| 18525026 | Differential association of Orc1 and Sir2 proteins to telomeric domains inPlasmodium falciparum. | Mancio-Silva L, Rojas-Meza AP, ..., Hernandez-Rivas R | 10.1242/jcs.026427 |
| 19633266 | Functional dissection of the catalytic carboxyl-terminal domain of originrecognition complex subunit 1 (PfORC1) of the human malaria parasite Plasmodiumfalciparum. | Gupta A, Mehra P, ..., Dhar SK | 10.1128/EC.00170-09 |
| 22379140 | The role of N-terminus of Plasmodium falciparum ORC1 in telomeric localizationand var gene silencing. | Deshmukh AS, Srivastava S, ..., Dhar SK | 10.1093/nar/gks202 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 26094711 | Regulation of Plasmodium falciparum Origin Recognition Complex subunit 1 (PfORC1)function through phosphorylation mediated by CDK-like kinase PK5. | Deshmukh AS, Agarwal M, ..., Dhar SK | 10.1111/mmi.13099 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 36808528 | A genome-wide map of DNA replication at single-molecule resolution in the malariaparasite Plasmodium falciparum | Totanes FIG, Gockel J, ..., Merrick CJ | 10.1093/nar/gkad093 |