About Gene List

PF3D7_1203100

Genome location: Pf3D7_12_v3:171,338..172,574(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 0.49 0.77
Trophozoite expressed 0.50 0.71
Schizont expressed 0.14 0.91
Gametocyte expressed 0.69 0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1203100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.2 | MFS: -2.655 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I614

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533407

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 12 8 10
disruptive 11 29 20 39
missense 11 28 19 34

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 4 20 13 10
disruptive 15 75 21 49
missense 12 65 19 41

PlasmoDB Total SNPs: 82

Non-coding: 74 | Synonymous: 4 | Nonsynonymous: 3 | Stop Codon: 1

Protein Information

Protein Length: 170 | Molecular Weight (kDa): 20.323

UniProt ID(s): Q8I614

PDB ID(s): None

Isoelectric Point: 9.74

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104