Product Description: signal recognition particle subunit SRP14
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005789 | endoplasmic reticulum membrane |
| Component | GO:0005634 | nucleus |
| Component | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting |
| Function | GO:0005515 | protein binding |
| Process | GO:0045047 | protein targeting to ER |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.24 | 0.88 |
| Trophozoite | possibly expressed | 0.28 | 0.82 |
| Schizont | possibly expressed | 0.06 | 0.95 |
| Gametocyte | expressed | 0.49 | 0.73 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1203200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.153 | MFS: -3.202 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I613
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103910
Most Similar Human Ortholog: P37108
TM-align score: 0.64 | RMSD: 2.50
Seq Identity: 0.36 | Length: 78 / 104
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000140319 | signal recognition particle 14 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 8 | 2 | 9 |
| disruptive | 1 | 10 | 6 | 17 |
| missense | 1 | 10 | 6 | 16 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 17 | 3 | 8 |
| disruptive | 3 | 26 | 19 | 31 |
| missense | 3 | 20 | 19 | 13 |
PlasmoDB Total SNPs: 62
Non-coding: 47 | Synonymous: 8 | Nonsynonymous: 7 | Stop Codon: 0
Protein Length: 104 | Molecular Weight (kDa): 11.862
PDB ID(s): None
Isoelectric Point: 10.52
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003210 | Signal recognition particle, SRP14 subunit |
| InterPro | IPR009018 | Signal recognition particle, SRP9/SRP14 subunit |
| PFam | PF02290 | Signal recognition particle, SRP14 subunit |
| Superfamily | SSF54762 | Signal recognition particle, SRP9/SRP14 subunit |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 24434517 | Plasmodium falciparum signal recognition particle components and anti-parasiticeffect of ivermectin in blocking nucleo-cytoplasmic shuttling of SRP. | Panchal M, Rawat K, ..., Tuteja R | 10.1038/cddis.2013.521 |