PF3D7_1203300

Genome location: Pf3D7_12_v3:173,597..177,277(-)

Genome classification: Core

Function and Localization

Product Description: TBCC domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Process	GO:0009657	plastid organization

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.10	0.95
Trophozoite	expressed	0.50	0.71
Schizont	expressed	0.34	0.79
Gametocyte	expressed	0.67	0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1203300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.138 | MFS: -3.114 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I612

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_211095

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	15	54	14	53
disruptive	62	124	77	175
missense	41	94	64	130

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	22	85	42	70
disruptive	97	288	120	261
missense	58	211	85	153

PlasmoDB Total SNPs: 244

Non-coding: 63 | Synonymous: 82 | Nonsynonymous: 99 | Stop Codon: 0

Protein Information

Protein Length: 992 | Molecular Weight (kDa): 117.534

UniProt ID(s): Q8I612

PDB ID(s): None

Isoelectric Point: 8.19

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR012945	Tubulin binding cofactor C-like domain
InterPro	IPR039589	TBCC domain-containing protein 1
PFam	PF07986	Tubulin binding cofactor C-like domain
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
30726238	A mutagenesis screen for essential plastid biogenesis genes in human malariaparasites.	Tang Y, Meister TR, ..., Yeh E	10.1371/journal.pbio.3000136