Product Description: major facilitator superfamily domain-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 12
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0016020 | membrane |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | expressed | N/A | N/A |
Ring | expressed | 0.07 | 0.97 |
Trophozoite | expressed | 0.53 | 0.69 |
Schizont | expressed | 0.51 | 0.68 |
Gametocyte | expressed | 0.46 | 0.73 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1203400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.3 | #Insertions: 4
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PbANKA_0602400)
Modification: Disrupted | RMgm-4332
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I611
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 23 | 98 | 39 | 86 |
disruptive | 75 | 190 | 109 | 240 |
missense | 46 | 149 | 96 | 193 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 42 | 168 | 47 | 95 |
disruptive | 131 | 413 | 200 | 494 |
missense | 72 | 314 | 145 | 261 |
PlasmoDB Total SNPs: 297
Non-coding: 97 | Synonymous: 74 | Nonsynonymous: 126 | Stop Codon: 0
Protein Length: 1250 | Molecular Weight (kDa): 149.196
PDB ID(s): None
Isoelectric Point: 8.11
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR036259 | MFS transporter superfamily |
PFam | N/A | N/A |
Superfamily | SSF103473 | MFS transporter superfamily |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |