Product Description: nucleosome assembly protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Function | GO:0003682 | chromatin binding |
| Function | GO:0042393 | histone binding |
| Function | GO:0005515 | protein binding |
| Process | GO:0006334 | nucleosome assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 2.14 | 0.22 |
| Trophozoite | expressed | 2.03 | 0.18 |
| Schizont | expressed | 0.97 | 0.48 |
| Gametocyte | expressed | 1.13 | 0.44 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1203700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.139 | MFS: -3.031 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0602700)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I608
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100833
Most Similar Human Ortholog: H0YCI4
TM-align score: 0.75 | RMSD: 2.84
Seq Identity: 0.35 | Length: 178 / 347
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000187109 | nucleosome assembly protein 1 like 1 |
| ENSG00000205531 | nucleosome assembly protein 1 like 4 |
| ENSG00000273562 | nucleosome assembly protein 1 like 4 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 27 | 16 | 22 |
| disruptive | 0 | 2 | 5 | 19 |
| missense | 0 | 2 | 4 | 15 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 49 | 17 | 24 |
| disruptive | 1 | 20 | 19 | 101 |
| missense | 0 | 16 | 16 | 68 |
PlasmoDB Total SNPs: 191
Non-coding: 171 | Synonymous: 19 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 347 | Molecular Weight (kDa): 40.488
UniProt ID(s): Q8I608
Isoelectric Point: 4.49
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002164 | Nucleosome assembly protein (NAP) |
| InterPro | IPR037231 | NAP-like superfamily |
| PFam | PF00956 | Nucleosome assembly protein (NAP) |
| Superfamily | SSF143113 | NAP-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 15899528 | Biochemical characterization of the two nucleosome assembly proteins fromPlasmodium falciparum. | Chandra BR, Olivieri A, ..., Sharma A | 10.1016/j.molbiopara.2005.04.006 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 16638744 | The two Plasmodium falciparum nucleosome assembly proteins play distinct roles inhistone transport and chromatin assembly. | Navadgi VM, Chandra BR, Mishra PC, Sharma A | 10.1074/jbc.M602243200 |
| 22293287 | Involvement of Plasmodium falciparum protein kinase CK2 in the chromatin assemblypathway. | Dastidar EG, Dayer G, ..., Doerig C | 10.1186/1741-7007-10-5 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |