PF3D7_1204100

Genome location: Pf3D7_12_v3:198,957..202,640(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.27	0.87
Trophozoite	expressed	0.30	0.82
Schizont	possibly expressed	0.58	0.72
Gametocyte	expressed	0.44	0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1204100

Resistome Missense Mutations: N579H, E580Q, Q583H

Resistome Compounds with Missense Mutations: Cipargamin/KAE609/NITD609, Proguanil

Resistome # Samples with Disruptive Mutations: 16 (15 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.354 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0603000)

Modification: Disrupted | RMgm-2061

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I605

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532512

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	20	44	26	75
disruptive	111	237	96	264
missense	56	168	79	205

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	29	94	43	77
disruptive	176	447	164	354
missense	95	317	127	217

PlasmoDB Total SNPs: 209

Non-coding: 35 | Synonymous: 80 | Nonsynonymous: 94 | Stop Codon: 0

Protein Information

Protein Length: 1089 | Molecular Weight (kDa): 131.53

UniProt ID(s): Q8I605

PDB ID(s): None

Isoelectric Point: 9.21

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A