PF3D7_1204200

Genome location: Pf3D7_12_v3:202,895..204,937(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	expressed	0.27	0.84
Schizont	possibly expressed	0.07	0.95
Gametocyte	expressed	0.60	0.68

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1204200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -2.551 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I604

"Best" AlphaFill ligand hit: LPA (lipoic acid, Local RMSD=11.48) with 5T8U (Global RMSD=24.40)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532578

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	14	32	19	28
disruptive	57	95	47	106
missense	31	69	34	83

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	21	61	27	50
disruptive	99	172	75	194
missense	50	123	56	121

PlasmoDB Total SNPs: 122

Non-coding: 24 | Synonymous: 50 | Nonsynonymous: 48 | Stop Codon: 0

Protein Information

Protein Length: 629 | Molecular Weight (kDa): 76.203

UniProt ID(s): Q8I604

PDB ID(s): None

Isoelectric Point: 8.6

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
PFam	N/A	N/A
Superfamily	SSF52540	P-loop containing nucleoside triphosphate hydrolase