Product Description: eukaryotic translation initiation factor 5A
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003746 | translation elongation factor activity |
| Function | GO:0003743 | translation initiation factor activity |
| Process | GO:0045901 | positive regulation of translational elongation |
| Process | GO:0006413 | translational initiation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.01 | 0.56 |
| Trophozoite | expressed | 1.59 | 0.31 |
| Schizont | expressed | 0.82 | 0.58 |
| Gametocyte | expressed | 0.58 | 0.68 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1204300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 1 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I603
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100628
Most Similar Human Ortholog: C9J4W5
TM-align score: 0.94 | RMSD: 1.00
Seq Identity: 0.57 | Length: 115 / 161
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000132507 | eukaryotic translation initiation factor 5A |
| ENSG00000163577 | eukaryotic translation initiation factor 5A2 |
| ENSG00000253626 | eukaryotic translation initiation factor 5A like 1 |
| ENSG00000288145 | eukaryotic translation initiation factor 5A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 1 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 1 | 0 |
| disruptive | 0 | 0 | 0 | 3 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 127
Non-coding: 126 | Synonymous: 1 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 161 | Molecular Weight (kDa): 17.631
PDB ID(s): None
Isoelectric Point: 5.53
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001884 | Translation elongation factor IF5A-like |
| InterPro | IPR008991 | Translation protein SH3-like domain superfamily |
| InterPro | IPR012340 | Nucleic acid-binding, OB-fold |
| InterPro | IPR019769 | Translation elongation factor, IF5A, hypusine site |
| InterPro | IPR020189 | Translation elongation factor, IF5A C-terminal |
| PFam | PF01287 | Translation elongation factor, IF5A C-terminal |
| Superfamily | SSF50104 | Translation protein SH3-like domain superfamily |
| Superfamily | SSF50249 | Nucleic acid-binding, OB-fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 38229033 | SUMOylation modulates eIF5A activities in both yeast and pancreatic ductaladenocarcinoma cells | Seoane R, Lama-Diaz T, ..., Rivas C | 10.1186/s11658-024-00533-5 |
| 38339043 | The Deficiency of Hypusinated eIF5A Decreases the Putrescine/Spermidine Ratio andInhibits +1 Programmed Ribosomal Frameshifting during the Translation of Ty1Retrotransposon in Saccharomyces cerevisiae | Xiao Y, Wang R, ..., Liang A | 10.3390/ijms25031766 |
| 38276673 | Toxoplasma gondii eIF-5A Modulates the Immune Response of Murine Macrophages InVitro | Liu X, Li X, ..., Li X | 10.3390/vaccines12010101 |