Product Description: sexual stage-specific protein G37, putative
SignalP Peptide: MRIPPFLIILFFVFYKKFNVNC
# Transmembrane Domains: 7
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0009986 | cell surface |
| Component | GO:0005886 | plasma membrane |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 1.00 |
| Trophozoite | not expressed | 0.00 | 1.00 |
| Schizont | expressed | 0.01 | 1.00 |
| Gametocyte | expressed | 0.68 | 0.67 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1204400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.999 | MFS: -2.254 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_0605800)
Modification: Disrupted | RMgm-4760
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I601
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 24 | 14 | 28 |
| disruptive | 5 | 39 | 27 | 52 |
| missense | 5 | 39 | 26 | 46 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 59 | 14 | 28 |
| disruptive | 10 | 100 | 39 | 83 |
| missense | 9 | 87 | 35 | 65 |
PlasmoDB Total SNPs: 186
Non-coding: 171 | Synonymous: 11 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 349 | Molecular Weight (kDa): 40.183
UniProt ID(s): Q8I601
PDB ID(s): None
Isoelectric Point: 8.89
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 29866905 | Characterization of Plasmodium berghei Pbg37 as Both a Pre- and Postfertilization Antigen with Transmission-Blocking Potential | Liu F, Li L, ..., Cao Y | 10.1128/IAI.00785-17 |
| 35355395 | Interaction of picolinamide fungicide primary metabolites UK-2A and CAS-649 withthe cytochrome bc(1) complex Qi site: mutation effects and modelling inSaccharomyces cerevisiae | Young DH, Meunier B, Wang NX | 10.1002/ps.6893 |
| 38098083 | A dual-antigen malaria vaccine targeting Pb22 and Pbg37 was able to induce robusttransmission-blocking activity | Gao W, Qiu Y, ..., Cao Y | 10.1186/s13071-023-06071-x |