PF3D7_1204500

Genome location: Pf3D7_12_v3:211,383..212,908(-)

Genome classification: Core

Function and Localization

Product Description: snRNA-activating protein complex subunit 1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.07	0.97
Trophozoite	possibly expressed	0.19	0.87
Schizont	not expressed	0.02	0.98
Gametocyte	possibly expressed	0.14	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1204500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.126 | MFS: -3.204 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0603400)

Relative Growth Rate: 0.07 ± 0.08
Confidence: 6.33

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I600

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_158754

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	18	11	24
disruptive	0	11	8	33
missense	0	11	7	31

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	36	12	31
disruptive	1	38	17	58
missense	0	35	17	43

PlasmoDB Total SNPs: 70

Non-coding: 54 | Synonymous: 14 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 279 | Molecular Weight (kDa): 33.303

UniProt ID(s): Q8I600

PDB ID(s): None

Isoelectric Point: 5.43

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR019188	Small nuclear RNA activating complex (SNAPc), subunit SNAP43
PFam	PF09808	Small nuclear RNA activating complex (SNAPc), subunit SNAP43
Superfamily	N/A	N/A