About Gene List

PF3D7_1205200 (HADO)

Genome location: Pf3D7_12_v3:225,821..227,226(-)

Genome classification: Core

Function and Localization

Product Description: HAD domain ookinete protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0045178 basal part of cell
Component GO:0005938 cell cortex
Component GO:0070258 inner membrane pellicle complex
Function GO:0016791 phosphatase activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.01 0.99
Trophozoite possibly expressed 0.04 0.97
Schizont expressed 0.24 0.83
Gametocyte possibly expressed 0.17 0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1205200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.132 | MFS: -3.193 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0603900)

  • Relative Growth Rate: 0.80 ± 0.23
  • Confidence: 4.35

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0603900)

Modification: Disrupted | RMgm-2065

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5Z3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_112929

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 17 10 18
disruptive 14 27 21 53
missense 4 24 18 46

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 38 9 27
disruptive 18 86 41 92
missense 6 66 33 60

PlasmoDB Total SNPs: 64

Non-coding: 42 | Synonymous: 15 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 338 | Molecular Weight (kDa): 39.197

UniProt ID(s): Q8I5Z3

PDB ID(s): None

Isoelectric Point: 8.88

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
25225164 Characterization of Plasmodium developmental transcriptomes in Anopheles gambiaemidgut reveals novel regulators of malaria transmission. Akinosoglou KA, Bushell ES, ..., Vlachou D 10.1111/cmi.12363
26840427 A MORN1-associated HAD phosphatase in the basal complex is essential forToxoplasma gondii daughter budding. Engelberg K, Ivey FD, ..., Gubbels MJ 10.1111/cmi.12574