About Gene List

PF3D7_1205300

Genome location: Pf3D7_12_v3:230,037..231,763(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MLLKYRCIILFLCIFRNNILVHS

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.02 0.99
Trophozoite expressed 0.20 0.86
Schizont expressed 0.09 0.93
Gametocyte expressed 0.06 0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1205300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.25 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZZL4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215358

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 22 17 19
disruptive 9 36 23 82
missense 9 36 23 71

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 42 14 21
disruptive 16 87 53 102
missense 15 75 45 67

PlasmoDB Total SNPs: 140

Non-coding: 119 | Synonymous: 17 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 314 | Molecular Weight (kDa): 38.243

UniProt ID(s): A0A143ZZL4

PDB ID(s): None

Isoelectric Point: 10.05

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895