PF3D7_1205400

Genome location: Pf3D7_12_v3:232,330..236,562(-)

Genome classification: Core

Function and Localization

Product Description: kelch domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.45	0.78
Trophozoite	expressed	0.56	0.68
Schizont	expressed	0.59	0.64
Gametocyte	possibly expressed	0.59	0.68

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1205400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.114 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5Z1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533299

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	16	61	39	80
disruptive	40	168	92	213
missense	39	161	91	195

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	25	130	66	85
disruptive	85	354	134	345
missense	76	304	115	255

PlasmoDB Total SNPs: 238

Non-coding: 117 | Synonymous: 61 | Nonsynonymous: 60 | Stop Codon: 0

Protein Information

Protein Length: 1085 | Molecular Weight (kDa): 128.462

UniProt ID(s): Q8I5Z1

PDB ID(s): None

Isoelectric Point: 8.21

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006652	Kelch repeat type 1
InterPro	IPR011043	Galactose oxidase/kelch, beta-propeller
InterPro	IPR015915	Kelch-type beta propeller
PFam	PF01344	Kelch repeat type 1
PFam	PF13418
Superfamily	SSF117281	Kelch-type beta propeller
Superfamily	SSF50965	Galactose oxidase/kelch, beta-propeller