PF3D7_1205500

Genome location: Pf3D7_12_v3:241,557..248,411(+)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1205500

Resistome Missense Mutations: H689P

Resistome Compounds with Missense Mutations: TCMDC-124553/MMV019869

Resistome # Samples with Disruptive Mutations: 3 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.234 | #Insertions: 8

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5Z0

"Best" AlphaFill ligand hit: No AlphaFill hits

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_125165

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 326

Non-coding: 141 | Synonymous: 92 | Nonsynonymous: 92 | Stop Codon: 1

Protein Information

Protein Length: 1785 | Molecular Weight (kDa): 204.851

UniProt ID(s): Q8I5Z0

PDB ID(s): None

Isoelectric Point: 6.3

Protein Domain Annotations: