PF3D7_1205600

Genome location: Pf3D7_12_v3:248,691..252,115(-)

Genome classification: Core

Function and Localization

Product Description: tetratricopeptide repeat protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005654	nucleoplasm
Component	GO:0005634	nucleus
Function	GO:0042393	histone binding
Process	GO:0034080	CENP-A containing chromatin assembly
Process	GO:0006335	DNA replication-dependent chromatin assembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.37	0.84
Trophozoite	expressed	1.78	0.27
Schizont	expressed	0.24	0.86
Gametocyte	expressed	1.13	0.49

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1205600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.149 | MFS: -2.679 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0604300)

Relative Growth Rate: 0.21 ± 0.27
Confidence: 3.98

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5Y9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_126747

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	32	11	38
disruptive	5	20	11	43
missense	5	18	10	38

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	57	22	32
disruptive	12	50	24	94
missense	8	39	24	69

PlasmoDB Total SNPs: 234

Non-coding: 218 | Synonymous: 13 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 333 | Molecular Weight (kDa): 39.018

UniProt ID(s): Q8I5Y9

PDB ID(s): None

Isoelectric Point: 4.55

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011990	Tetratricopeptide-like helical domain superfamily
InterPro	IPR019544	Tetratricopeptide, SHNi-TPR domain
PFam	PF10516	Tetratricopeptide, SHNi-TPR domain
Superfamily	SSF48452	Tetratricopeptide-like helical domain superfamily

Associated Publications

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108
28798222	An Integrated Approach to Explore Composition and Dynamics of Cholesterol-richMembrane Microdomains in Sexual Stages of Malaria Parasite.	Fratini F, Raggi C, ..., Ponzi M	10.1074/mcp.M117.067041
30379851	Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation.	Briquet S, Ourimi A, ..., Vaquero C	10.1371/journal.pone.0205596