Product Description: high mobility group protein B3, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 2.12 | 0.22 |
| Trophozoite | expressed | 1.77 | 0.25 |
| Schizont | expressed | 1.84 | 0.22 |
| Gametocyte | expressed | 1.16 | 0.43 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1205800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.862 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5Y7
"Best" AlphaFill ligand hit: XMP (xanthosine-5'-monophosphate, Local RMSD=0.62) with 3BPW (Global RMSD=19.69)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 29 | 128 | 71 | 166 |
| disruptive | 158 | 357 | 193 | 469 |
| missense | 70 | 269 | 158 | 390 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 52 | 260 | 93 | 181 |
| disruptive | 240 | 773 | 315 | 679 |
| missense | 114 | 573 | 261 | 474 |
PlasmoDB Total SNPs: 439
Non-coding: 112 | Synonymous: 187 | Nonsynonymous: 138 | Stop Codon: 2
Protein Length: 2284 | Molecular Weight (kDa): 267.019
UniProt ID(s): Q8I5Y7
PDB ID(s): None
Isoelectric Point: 6.65
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001005 | SANT/Myb domain |
| InterPro | IPR009057 | Homeobox-like domain superfamily |
| InterPro | IPR009071 | High mobility group box domain |
| InterPro | IPR036910 | High mobility group box domain superfamily |
| InterPro | IPR039467 | Transcription factor TFIIIB component B'', Myb domain |
| PFam | PF15963 | Transcription factor TFIIIB component B'', Myb domain |
| Superfamily | SSF46689 | Homeobox-like domain superfamily |
| Superfamily | SSF47095 | High mobility group box domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 37359246 | CircSLCO3A1 depletion ameliorates lipopolysaccharide-induced inflammation andapoptosis of human pulmonary alveolar epithelial cells through themiR-424-5p/HMGB3 pathway | Li Y, Zhang C, Zhao Z | 10.1007/s13273-023-00341-6 |