PF3D7_1205900

Genome location: Pf3D7_12_v3:264,233..267,884(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 5

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.74	0.66
Trophozoite	expressed	0.97	0.49
Schizont	expressed	0.81	0.54
Gametocyte	expressed	0.83	0.55

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1205900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.142 | MFS: -2.817 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5Y6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102131

Most Similar Human Ortholog: A0A075B6H3

TM-align score: 0.71 | RMSD: 3.37

Seq Identity: 0.29 | Length: 453 / 1082

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000162542	transmembrane and coiled-coil domains 4

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	45	51	84
disruptive	25	101	74	157
missense	11	86	63	132

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	19	128	59	76
disruptive	52	239	117	265
missense	24	193	101	191

PlasmoDB Total SNPs: 126

Non-coding: 45 | Synonymous: 52 | Nonsynonymous: 29 | Stop Codon: 0

Protein Information

Protein Length: 1082 | Molecular Weight (kDa): 124.158

UniProt ID(s): Q8I5Y6

PDB ID(s): None

Isoelectric Point: 6.06

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR007941	Protein of unknown function DUF726
InterPro	IPR029058	Alpha/Beta hydrolase fold
PFam	PF05277	Protein of unknown function DUF726
Superfamily	SSF53474	Alpha/Beta hydrolase fold

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104