Product Description: shewanella-like protein phosphatase 2
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.1.3.16 (Protein-serine/threonine phosphatase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0045177 | apical part of cell |
| Component | GO:0043657 | host cell |
| Component | GO:0005634 | nucleus |
| Component | GO:0048471 | perinuclear region of cytoplasm |
| Function | GO:0004725 | protein tyrosine phosphatase activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 1.00 |
| Trophozoite | expressed | 0.02 | 0.99 |
| Schizont | expressed | 0.50 | 0.72 |
| Gametocyte | possibly expressed | 0.03 | 0.98 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1206000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.559 | #Insertions: 3
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0604700)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0604700)
Modification: Disrupted | RMgm-2068
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5Y5
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.1.3.16 | protein-serine/threonine phosphatase | ATPADPUDPAMPGTPUTPUMPNaFEDTAEGTAcAMPNADPH... |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 130
Non-coding: 109 | Synonymous: 15 | Nonsynonymous: 6 | Stop Codon: 0
Protein Length: 304 | Molecular Weight (kDa): 35.686
UniProt ID(s): Q8I5Y5
PDB ID(s): None
Isoelectric Point: 8.98
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004843 | Calcineurin-like phosphoesterase domain, ApaH type |
| PFam | PF00149 | Calcineurin-like phosphoesterase domain, ApaH type |
| Superfamily | SSF56300 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 20037583 | Transcriptional profiling of growth perturbations of the human malaria parasitePlasmodium falciparum. | Hu G, Cabrera A, ..., Bozdech Z | 10.1038/nbt.1597 |
| 23825180 | A bacterial phosphatase-like enzyme of the malaria parasite Plasmodium falciparumpossesses tyrosine phosphatase activity and is implicated in the regulation ofband 3 dynamics during parasite invasion. | Fernandez-Pol S, Slouka Z, ..., Haldar K | 10.1128/EC.00027-13 |
| 25011111 | Genome-wide functional analysis of Plasmodium protein phosphatases reveals keyregulators of parasite development and differentiation. | Guttery DS, Poulin B, ..., Tewari R | 10.1016/j.chom.2014.05.020 |
| 29073264 | Shelph2, a bacterial-like phosphatase of the malaria parasite Plasmodiumfalciparum, is dispensable during asexual blood stage. | Miliu A, Lebrun M, Braun-Breton C, Lamarque MH | 10.1371/journal.pone.0187073 |
| 31555028 | Homology Modeling and Docking Study of Shewanella-like Protein PhosphataseInvolved in the Development of Ookinetes in Plasmodium | Singh S, Yadav R | 10.4103/jpbs.JPBS_205_18 |