Product Description: eukaryotic translation initiation factor 3 subunit C, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005852 | eukaryotic translation initiation factor 3 complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0003729 | mRNA binding |
| Function | GO:0003743 | translation initiation factor activity |
| Function | GO:0031369 | translation initiation factor binding |
| Process | GO:0006446 | regulation of translational initiation |
| Process | GO:0006413 | translational initiation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.70 | 0.33 |
| Trophozoite | expressed | 1.88 | 0.21 |
| Schizont | expressed | 0.48 | 0.73 |
| Gametocyte | expressed | 1.26 | 0.40 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1206200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.123 | MFS: -2.98 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0604800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5Y3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101999
Most Similar Human Ortholog: H3BTY8
TM-align score: 0.75 | RMSD: 1.72
Seq Identity: 0.32 | Length: 72 / 984
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000184110 | eukaryotic translation initiation factor 3 subunit C |
| ENSG00000205609 | eukaryotic translation initiation factor 3 subunit C like |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 47 | 18 | 66 |
| disruptive | 23 | 59 | 46 | 118 |
| missense | 15 | 45 | 37 | 92 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 16 | 98 | 36 | 64 |
| disruptive | 39 | 149 | 84 | 167 |
| missense | 23 | 103 | 73 | 120 |
PlasmoDB Total SNPs: 183
Non-coding: 126 | Synonymous: 38 | Nonsynonymous: 19 | Stop Codon: 0
Protein Length: 984 | Molecular Weight (kDa): 116.014
UniProt ID(s): Q8I5Y3
PDB ID(s): None
Isoelectric Point: 5.03
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000717 | Proteasome component (PCI) domain |
| InterPro | IPR008905 | Eukaryotic translation initiation factor 3 subunit C, N-terminal domain |
| InterPro | IPR027516 | Eukaryotic translation initiation factor 3 subunit C |
| InterPro | IPR036390 | Winged helix DNA-binding domain superfamily |
| PFam | PF01399 | Proteasome component (PCI) domain |
| PFam | PF05470 | Eukaryotic translation initiation factor 3 subunit C, N-terminal domain |
| Superfamily | SSF46785 | Winged helix DNA-binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 27381095 | The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. | Bunnik EM, Batugedara G, ..., Le Roch KG | 10.1186/s13059-016-1014-0 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |