About Gene List

PF3D7_1206300

Genome location: Pf3D7_12_v3:280,814..289,619(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.15 0.93
Trophozoite not expressed 0.51 0.73
Schizont possibly expressed 2.19 0.28
Gametocyte possibly expressed 1.11 0.49

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1206300

Resistome Missense Mutations: M1988K

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.599 | MFS: -2.564 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533338

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 16 80 56 151
disruptive 131 356 213 471
missense 82 288 168 382

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 26 179 83 146
disruptive 255 740 296 621
missense 125 566 236 445

PlasmoDB Total SNPs: 433

Non-coding: 45 | Synonymous: 190 | Nonsynonymous: 198 | Stop Codon: 0

Protein Information

Protein Length: 2760 | Molecular Weight (kDa): 330.872

UniProt ID(s): A0A143ZZM5

PDB ID(s): None

Isoelectric Point: 8.55

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21