PF3D7_1206500

Genome location: Pf3D7_12_v3:292,233..294,941(+)

Genome classification: Core

Function and Localization

Product Description: Tat binding protein 1(TBP-1)-interacting protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.07	0.96
Schizont	not expressed	0.06	0.95
Gametocyte	expressed	0.81	0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1206500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.178 | #Insertions: 4

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0605100)

Relative Growth Rate: 1.06 ± 0.10
Confidence: 5.95

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0605100)

Modification: Disrupted | RMgm-2070

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5Y0

"Best" AlphaFill ligand hit: FMN (flavin mononucleotide, Local RMSD=0.68) with 1TV5 (Global RMSD=16.98)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103529

Most Similar Human Ortholog: K7EQS1

TM-align score: 0.84 | RMSD: 1.75

Seq Identity: 0.22 | Length: 110 / 651

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000131470	PSMC3 interacting protein

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	27	16	29
disruptive	12	67	52	145
missense	10	61	49	125

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	49	26	39
disruptive	40	176	75	175
missense	18	146	67	133

PlasmoDB Total SNPs: 113

Non-coding: 21 | Synonymous: 55 | Nonsynonymous: 37 | Stop Codon: 0

Protein Information

Protein Length: 651 | Molecular Weight (kDa): 76.411

UniProt ID(s): Q8I5Y0

PDB ID(s): None

Isoelectric Point: 9.74

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR010776	Homologous-pairing protein 2, winged helix domain
InterPro	IPR040461	Homologous-pairing protein 2
PFam	PF07106	Homologous-pairing protein 2, winged helix domain
Superfamily	N/A	N/A