Product Description: eukaryotic translation initiation factor 5, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
| Component | GO:0005634 | nucleus |
| Function | GO:0005092 | GDP-dissociation inhibitor activity |
| Function | GO:0071074 | eukaryotic initiation factor eIF2 binding |
| Function | GO:0005515 | protein binding |
| Function | GO:0003743 | translation initiation factor activity |
| Process | GO:0001732 | formation of cytoplasmic translation initiation complex |
| Process | GO:0001731 | formation of translation preinitiation complex |
| Process | GO:0006446 | regulation of translational initiation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.54 | 0.74 |
| Trophozoite | expressed | 0.67 | 0.62 |
| Schizont | expressed | 0.33 | 0.79 |
| Gametocyte | expressed | 0.41 | 0.76 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1206700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.366 | MFS: -2.497 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0605300)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5X8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101859
Most Similar Human Ortholog: H0YM54
TM-align score: 0.97 | RMSD: 0.71
Seq Identity: 0.53 | Length: 109 / 565
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000100664 | eukaryotic translation initiation factor 5 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 1 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 1 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 1 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 1 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 283
Non-coding: 256 | Synonymous: 18 | Nonsynonymous: 9 | Stop Codon: 0
Protein Length: 565 | Molecular Weight (kDa): 64.544
UniProt ID(s): Q8I5X8
PDB ID(s): None
Isoelectric Point: 5.52
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002735 | Translation initiation factor IF2/IF5 |
| InterPro | IPR016024 | Armadillo-type fold |
| InterPro | IPR016189 | Translation initiation factor IF2/IF5, N-terminal |
| InterPro | IPR016190 | Translation initiation factor IF2/IF5, zinc-binding |
| PFam | PF01873 | Translation initiation factor IF2/IF5 |
| Superfamily | SSF100966 | Translation initiation factor IF2/IF5, N-terminal |
| Superfamily | SSF48371 | Armadillo-type fold |
| Superfamily | SSF75689 | Translation initiation factor IF2/IF5, zinc-binding |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 27303372 | Identification of Plasmodium falciparum Translation Initiation eIF2beta Subunit:Direct Interaction with Protein Phosphatase Type 1. | Tellier G, Lenne A, ..., Khalife J | 10.3389/fmicb.2016.00777 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |