PF3D7_1206800

Genome location: Pf3D7_12_v3:308,165..310,829(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.09	0.96
Trophozoite	expressed	0.21	0.87
Schizont	possibly expressed	0.06	0.96
Gametocyte	not expressed	0.37	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1206800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.206 | MFS: -3.331 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0605400)

Relative Growth Rate: 0.14 ± 0.11
Confidence: 5.79

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5X7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533095

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	43	24	53
disruptive	9	76	58	135
missense	9	69	52	125

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	98	27	52
disruptive	26	200	118	261
missense	21	163	98	136

PlasmoDB Total SNPs: 94

Non-coding: 41 | Synonymous: 38 | Nonsynonymous: 13 | Stop Codon: 2

Protein Information

Protein Length: 727 | Molecular Weight (kDa): 86.315

UniProt ID(s): Q8I5X7

PDB ID(s): None

Isoelectric Point: 6.54

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A