About Gene List

PF3D7_1207000

Genome location: Pf3D7_12_v3:313,352..322,762(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.16 0.93
Trophozoite possibly expressed 1.16 0.45
Schizont possibly expressed 1.36 0.39
Gametocyte possibly expressed 0.84 0.58

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1207000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.871 | #Insertions: 7

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5X5

"Best" AlphaFill ligand hit: UDP (uridine-5'-diphosphate, Local RMSD=0.05) with 5H62 (Global RMSD=19.24)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_171516

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 29 116 89 188
disruptive 109 344 214 540
missense 68 284 184 476

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 51 254 128 195
disruptive 177 769 356 714
missense 106 621 309 509

PlasmoDB Total SNPs: 371

Non-coding: 104 | Synonymous: 150 | Nonsynonymous: 117 | Stop Codon: 0

Protein Information

Protein Length: 2612 | Molecular Weight (kDa): 311.423

UniProt ID(s): Q8I5X5

PDB ID(s): None

Isoelectric Point: 8.29

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21