PF3D7_1207100

Genome location: Pf3D7_12_v3:323,839..327,795(-)

Genome classification: Core

Function and Localization

Product Description: pre-rRNA-processing protein ESF1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0003723	RNA binding
Process	GO:0006364	rRNA processing

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	1.73	0.31
Trophozoite	expressed	1.29	0.38
Schizont	expressed	0.73	0.59
Gametocyte	not expressed	1.10	0.45

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1207100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.992 | MFS: -2.589 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0605700)

Relative Growth Rate: 0.04 ± 0.05
Confidence: 7.45

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5X4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533509

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	42	25	72
disruptive	16	109	68	169
missense	14	104	64	151

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	15	96	36	73
disruptive	43	287	133	286
missense	27	241	113	187

PlasmoDB Total SNPs: 164

Non-coding: 108 | Synonymous: 32 | Nonsynonymous: 24 | Stop Codon: 0

Protein Information

Protein Length: 840 | Molecular Weight (kDa): 100.169

UniProt ID(s): Q86BT8, Q8I5X4

PDB ID(s): None

Isoelectric Point: 6.35

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR012580	NUC153
InterPro	IPR039754	Pre-rRNA-processing protein Esf1
PFam	PF08159	NUC153
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104