About Gene List

PF3D7_1207200

Genome location: Pf3D7_12_v3:328,655..339,145(-)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0016020 membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.03 0.98
Trophozoite possibly expressed 0.35 0.79
Schizont not expressed 0.21 0.86
Gametocyte not expressed 0.55 0.71

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1207200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.651 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533476

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 26 118 99 216
disruptive 130 569 366 738
missense 91 504 326 653

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 42 308 158 213
disruptive 231 1315 484 979
missense 154 1131 383 646

PlasmoDB Total SNPs: 474

Non-coding: 129 | Synonymous: 157 | Nonsynonymous: 186 | Stop Codon: 2

Protein Information

Protein Length: 2723 | Molecular Weight (kDa): 326.483

UniProt ID(s): Q8I5X3

PDB ID(s): None

Isoelectric Point: 8.92

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097