About Gene List

PF3D7_1207300 (LIMP)

Genome location: Pf3D7_12_v3:343,326..344,361(-)

Genome classification: Core

Function and Localization

Product Description: LIMP protein, putative

SignalP Peptide: MWEKILFFIVLIFPFFHSCEA

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0009986 cell surface
Component GO:0044312 crystalloid
Process GO:0071976 cell gliding
Process GO:0044409 entry into host

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.00 1.00
Trophozoite possibly expressed 0.01 1.00
Schizont possibly expressed 0.00 1.00
Gametocyte possibly expressed 0.62 0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1207300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.99 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0605800)

Modification: Tagged | RMgm-4168

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5X2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533597

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 6 1 8
disruptive 1 17 8 16
missense 1 17 8 14

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 4 9 2 12
disruptive 2 34 22 38
missense 2 31 19 26

PlasmoDB Total SNPs: 48

Non-coding: 44 | Synonymous: 4 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 109 | Molecular Weight (kDa): 13.316

UniProt ID(s): Q8I5X2

PDB ID(s): None

Isoelectric Point: 7.97

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
28525314 Malaria parasite L IMP protein regulates sporozoite gliding motility andinfectivity in mosquito and mammalian hosts Santos JM, Egarter S, ..., Mair GR 10.7554/eLife.24109