PF3D7_1207400

Genome location: Pf3D7_12_v3:345,922..347,239(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	not expressed	0.01	0.99
Schizont	possibly expressed	0.01	0.99
Gametocyte	expressed	0.14	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1207400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.137 | MFS: -2.975 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0605900)

Modification: Mutated | RMgm-4742

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5X1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532772

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	20	15	32
disruptive	33	52	39	93
missense	13	32	24	59

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	44	16	28
disruptive	42	133	66	136
missense	14	73	47	86

PlasmoDB Total SNPs: 58

Non-coding: 6 | Synonymous: 26 | Nonsynonymous: 26 | Stop Codon: 0

Protein Information

Protein Length: 395 | Molecular Weight (kDa): 46.958

UniProt ID(s): Q8I5X1

PDB ID(s): None

Isoelectric Point: 4.36

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A